VDR is a gene that encodes for a vitamin D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene (rs2228570 FokI polymorphism) is associated with a decreased bone mineral density among white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the temporal and reciprocal pattern of on- and off occupancy of the VDRE by two components, and it is influenced by chromosomal locations and by binding preferences for certain hormones. Microarray studies of human cells demonstrate that more than 100 genes carry a distinct VDRE located in their promoters. The VDRE is occupied by transcription repressors in the absence check this site out of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository of data and documents that are relevant to legal transactions, business or proceedings that are restricted in viewing or downloading. It makes use of a central computer as well as an extranet, which is a restricted-access Internet connection that allows users to login at specified times.
VDRs are typically used by investment banks and companies involved in mergers or acquisitions. They must be able to share information in a transparent way with potential investors or buyers. Due diligence processes may also require a huge amount of information. Life science companies also use VDRs for everything from clinical trial data to HIPAA compliance documents.